Coert Margadant

Leiden, ZH 2333CC, Netherlands

Last Updated: 09/26/2026

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Found 42 publications

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation.

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation.

Journal: Science advances

Published: July 17, 2026

Maternal anti-HPA-1a antibodies block αIIbβ3 and αvβ3 integrin activation which correlates with FNAIT disease severity.

Maternal anti-HPA-1a antibodies block αIIbβ3 and αvβ3 integrin activation which correlates with FNAIT disease severity.

Journal: Blood

Published: September 16, 2025

Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity.

Maternal anti-HPA-1a antibodies block αIIbβ3/αvβ3 integrin activation, and blockade correlates with FNAIT disease severity.

Journal: Blood

Published: September 16, 2025

C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signaling.

C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signaling.

Journal: Cell communication and signaling : CCS

Published: June 18, 2025

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins.

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins.

Journal: Blood

Published: April 15, 2025

SCUBE2, where are you? Recruitment of SCUBE2 to adherens junctions preserves vascular health and integrity.

SCUBE2, where are you? Recruitment of SCUBE2 to adherens junctions preserves vascular health and integrity.

Journal: Cardiovascular research

Published: September 06, 2024

Integrin-Dependent Cell-Matrix Adhesion in Endothelial Health and Disease.

Integrin-Dependent Cell-Matrix Adhesion in Endothelial Health and Disease.

Journal: Circulation research

Published: February 02, 2023

Live-Cell Labeling and Artificial Intelligence Approaches for High-Resolution XYZT Imaging of Cytoskeletal Dynamics During Collective Cell Migration.

Live-Cell Labeling and Artificial Intelligence Approaches for High-Resolution XYZT Imaging of Cytoskeletal Dynamics During Collective Cell Migration.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: January 18, 2023

Cell Migration in Three Dimensions.

Cell Migration in Three Dimensions.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: January 18, 2023

Imaging and quantitative analysis of integrin-dependent cell-matrix adhesions.

Imaging and quantitative analysis of integrin-dependent cell-matrix adhesions.

Journal: STAR protocols

Published: November 30, 2022

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment.

Fetal and neonatal alloimmune thrombocytopenia: Current pathophysiological insights and perspectives for future diagnostics and treatment.

Journal: Blood reviews

Published: October 27, 2022

Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells.

Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells.

Journal: Research and practice in thrombosis and haemostasis

Published: June 09, 2022

Showing 1-12 of 42

Last Updated: 09/26/2026