Last Updated: 09/26/2026
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Found 68 publications
Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.
Journal: Archives of toxicology
Published: June 26, 2026
Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332.
Journal: Critical reviews in toxicology
Published: January 19, 2026
Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 06, 2025
The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.
Journal: Archives of toxicology
Published: January 16, 2025
Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone.
Journal: The Journal of pharmacology and experimental therapeutics
Published: November 24, 2024
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: February 05, 2024
Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism.
Journal: F1000Research
Published: March 07, 2023
In vivo stress reporters as early biomarkers of the cellular changes associated with progeria.
Journal: Journal of cellular and molecular medicine
Published: June 28, 2022
Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling.
Journal: British journal of cancer
Published: May 13, 2021
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.
Journal: Communications biology
Published: March 25, 2021
Last Updated: 09/26/2026