Daisuke Nakai
Tokyo, Japan
Last Updated: 09/26/2026
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Found 28 publications
Characterization of unusual pyrazole ring-rearranged metabolites of DS-1971a specific to monkeys.
Journal: Drug metabolism and pharmacokinetics
Published: March 17, 2026
Characterization of human intestinal organoid-derived monolayers under air-liquid interface culture for pharmacokinetics evaluation.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: January 21, 2026
Characterization of fatty acid amide hydrolase 2 as a drug-metabolizing enzyme: Contribution to the hydrolysis of DS-8500a and its analogs.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: September 30, 2025
Impact of degradation in subcutaneous tissue and lymphatic fluid on absorption of Fc-fusion proteins following subcutaneous administration.
Journal: Drug metabolism and pharmacokinetics
Published: March 10, 2025
Contribution of Japanese scientists to drug metabolism and disposition.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: December 29, 2024
Validation of a New Scoring Method to Assess the Efficacy of Rapid Initiation and Titration of Combination Pharmacotherapy for Patients Hospitalized with Acute Decompensated Heart Failure with Reduced and Mildly Reduced Ejection Fraction.
Journal: Journal of clinical medicine
Published: March 26, 2024
Intestinal Membrane Function in Inflammatory Bowel Disease.
Journal: Pharmaceutics
Published: October 31, 2023
Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies.
Journal: Pharmaceutics
Published: October 30, 2023
The change of the electrophysiological parameters using human intestinal tissues from ulcerative colitis and Crohn's disease.
Journal: Journal of pharmacological sciences
Published: March 30, 2022
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies.
Journal: Drug metabolism and pharmacokinetics
Published: September 16, 2021
Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent.
Journal: Bioorganic & medicinal chemistry letters
Published: September 09, 2021
Last Updated: 09/26/2026