Damian C. Crowther

AstraZeneca Granta Park
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 37 publications

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.

Journal: Nature communications

Published: February 13, 2025

The case for regulatory approval of amyloid-lowering immunotherapies in Alzheimer's disease based on clearcut biomarker evidence.

The case for regulatory approval of amyloid-lowering immunotherapies in Alzheimer's disease based on clearcut biomarker evidence.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: June 18, 2024

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Journal: Nature communications

Published: February 28, 2024

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.

Journal: Scientific reports

Published: April 30, 2021

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.

Journal: Brain communications

Published: March 24, 2021

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.

Journal: The EMBO journal

Published: September 14, 2018

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease.

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease.

Journal: The Journal of biological chemistry

Published: April 06, 2018

Central and peripheral circadian clocks and their role in Alzheimer's disease.

Central and peripheral circadian clocks and their role in Alzheimer's disease.

Journal: Disease models & mechanisms

Published: October 11, 2017

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

Journal: EMBO molecular medicine

Published: September 01, 2017

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Journal: Epileptic disorders : international epilepsy journal with videotape

Published: September 14, 2016

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.

Journal: Scientific reports

Published: May 26, 2016

CCT complex restricts neuropathogenic protein aggregation via autophagy.

CCT complex restricts neuropathogenic protein aggregation via autophagy.

Journal: Nature communications

Published: April 26, 2016

Showing 1-12 of 37

Last Updated: 09/26/2026