Last Updated: 09/26/2026
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Found 8 publications
The Discovery of GS-1291269: A Neutral Ketohexokinase (KHK) Inhibitor with an Unusual Thietane Amine Functional Group.
Journal: Journal of medicinal chemistry
Published: December 23, 2025
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
Journal: Journal of medicinal chemistry
Published: April 09, 2021
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Journal: Bioorganic & medicinal chemistry letters
Published: January 17, 2017
Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.
Journal: Bioorganic & medicinal chemistry letters
Published: March 31, 2015
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.
Journal: Journal of medicinal chemistry
Published: October 23, 2013
Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.
Journal: Journal of medicinal chemistry
Published: April 04, 2013
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Journal: Antimicrobial agents and chemotherapy
Published: November 28, 2012
Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease.
Journal: Bioorganic & medicinal chemistry letters
Published: October 06, 2011
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Last Updated: 09/26/2026