Daniel Oehlrich

Beerse, VLG 2340, Belgium

Last Updated: 09/26/2026

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Found 32 publications

Discovery of 5‑Azaindole Inhibitors of O‑GlcNAcase for the Treatment of Alzheimer's Disease and Related Tauopathies.

Discovery of 5‑Azaindole Inhibitors of O‑GlcNAcase for the Treatment of Alzheimer's Disease and Related Tauopathies.

Journal: ACS medicinal chemistry letters

Published: January 07, 2026

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

Journal: Journal of virology

Published: June 02, 2025

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.

Journal: Journal of medicinal chemistry

Published: March 05, 2025

Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.

Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.

Journal: Journal of medicinal chemistry

Published: February 11, 2025

Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.

Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.

Journal: EMBO molecular medicine

Published: May 23, 2024

Structural basis for the oligomerization-facilitated NLRP3 activation.

Structural basis for the oligomerization-facilitated NLRP3 activation.

Journal: Nature communications

Published: June 08, 2023

Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation.

Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation.

Journal: Science advances

Published: April 08, 2022

Publisher Correction: Post-translational insertion of boron in proteins to probe and modulate function.

Publisher Correction: Post-translational insertion of boron in proteins to probe and modulate function.

Journal: Nature chemical biology

Published: December 14, 2021

Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.

Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.

Journal: Molecular psychiatry

Published: October 15, 2021

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

Journal: ACS medicinal chemistry letters

Published: August 18, 2021

Post-translational insertion of boron in proteins to probe and modulate function.

Post-translational insertion of boron in proteins to probe and modulate function.

Journal: Nature chemical biology

Published: January 21, 2021

3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors.

3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: November 12, 2019

Showing 1-12 of 32

Last Updated: 09/26/2026