Daniela Siegmund
Wuerzburg, BY, Germany
Last Updated: 09/26/2026
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Found 32 publications
A simple and broadly applicable nanobody-based approach to generate potent TNFR agonists.
Journal: Cell death & disease
Published: August 06, 2025
Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins.
Journal: Cell chemical biology
Published: November 30, 2024
TRAF2 and RIPK1 redundantly mediate classical NFκB signaling by TNFR1 and CD95-type death receptors.
TRAF2 and RIPK1 redundantly mediate classical NFκB signaling by TNFR1 and CD95-type death receptors.
Journal: Cell death & disease
Published: April 30, 2024
Genetically engineered IgG1 and nanobody oligomers acquire strong intrinsic CD40 agonism.
Journal: Bioengineered
Published: January 12, 2024
Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling.
Journal: Frontiers in cell and developmental biology
Published: July 27, 2023
TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond.
Journal: Nature reviews. Rheumatology
Published: July 05, 2023
TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer.
Journal: Cancers
Published: July 07, 2022
Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist.
Journal: Cell death & disease
Published: November 19, 2020
Assessment of TP53 lesions for p53 system functionality and drug resistance in multiple myeloma using an isogenic cell line model.
Journal: Scientific reports
Published: September 19, 2019
TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling.
Journal: Frontiers in immunology
Published: April 17, 2019
The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death.
Journal: Cell death & disease
Published: April 14, 2019
TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages.
Journal: Frontiers in cell and developmental biology
Published: February 27, 2019
Last Updated: 09/26/2026