Danilo Guerini

Basel, BS 4056, Switzerland

Last Updated: 09/26/2026

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Found 13 publications

ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.

ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.

Journal: Cell reports
Published: December 13, 2023

Small molecule induced STING degradation facilitated by the HECT ligase HERC4.

Small molecule induced STING degradation facilitated by the HECT ligase HERC4.

Journal: Nature communications
Published: June 07, 2023

STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments.

STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments.

Journal: Cells
Published: January 29, 2022

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.

Journal: Cell reports
Published: March 22, 2021

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.

Journal: iScience
Published: February 23, 2021

Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.

Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.

Journal: ACS medicinal chemistry letters
Published: February 04, 2019

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.

Journal: Journal of medicinal chemistry
Published: January 24, 2018

Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kδ inhibitor leniolisib.

Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kδ inhibitor leniolisib.

Journal: Blood
Published: August 12, 2017

Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen.

Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen.

Journal: SLAS discovery : advancing life sciences R & D
Published: July 22, 2017

Second generation S1P pathway modulators: research strategies and clinical developments.

Second generation S1P pathway modulators: research strategies and clinical developments.

Journal: Biochimica et biophysica acta
Published: August 12, 2013

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization.

Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization.

Journal: British journal of pharmacology
Published: June 06, 2013

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.

Journal: British journal of pharmacology
Published: June 01, 2012
Showing 1-12 of 13

Last Updated: 09/26/2026