Daren Fearon

Diamond Light Source
Didcot, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 43 publications

X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1).

X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1).

Journal: Journal of medicinal chemistry

Published: July 13, 2026

Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain.

Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain.

Journal: Journal of medicinal chemistry

Published: May 19, 2026

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data.

Journal: Journal of chemical information and modeling

Published: February 26, 2026

Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches.

Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches.

Journal: ChemMedChem

Published: December 21, 2025

How many crystal structures do you need to trust your docking results?

How many crystal structures do you need to trust your docking results?

Journal: bioRxiv : the preprint server for biology

Published: October 03, 2025

Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals.

Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals.

Journal: Journal of medicinal chemistry

Published: September 02, 2025

A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral Discovery.

A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral Discovery.

Journal: bioRxiv : the preprint server for biology

Published: August 06, 2025

Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease.

Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease.

Journal: bioRxiv : the preprint server for biology

Published: July 16, 2025

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.

Journal: bioRxiv : the preprint server for biology

Published: July 16, 2025

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities.

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities.

Journal: Pest management science

Published: May 20, 2025

Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals.

Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals.

Journal: bioRxiv : the preprint server for biology

Published: April 16, 2025

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Journal: Research square

Published: February 24, 2025

Showing 1-12 of 43

Last Updated: 09/26/2026