Darren G. Monckton

Glasgow, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 76 publications

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene.

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene.

Journal: bioRxiv : the preprint server for biology

Published: August 20, 2026

Expanding repeats, expanding impact: Somatic instability in myotonic dystrophy type 1.

Expanding repeats, expanding impact: Somatic instability in myotonic dystrophy type 1.

Journal: Journal of neuromuscular diseases

Published: March 14, 2026

Genetic testing for Huntington's disease: Past, present and future. How could genetic data be used to improve clinical practice?

Genetic testing for Huntington's disease: Past, present and future. How could genetic data be used to improve clinical practice?

Journal: Journal of Huntington's disease

Published: December 23, 2025

Huntington disease: somatic expansion, pathobiology and therapeutics.

Huntington disease: somatic expansion, pathobiology and therapeutics.

Journal: Nature reviews. Neurology

Published: October 03, 2025

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease.

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease.

Journal: Movement disorders : official journal of the Movement Disorder Society

Published: June 24, 2025

Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and Severity.

Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and Severity.

Journal: JAMA ophthalmology

Published: March 13, 2025

International collaboration to improve knowledge on myotonic dystrophy type 2.

International collaboration to improve knowledge on myotonic dystrophy type 2.

Journal: Journal of neuromuscular diseases

Published: February 20, 2025

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Journal: Science translational medicine

Published: February 12, 2025

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis.

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis.

Journal: Nature medicine

Published: August 02, 2024

Ameliorated cellular hallmarks of myotonic dystrophy in hybrid myotubes from patient and unaffected donor cells.

Ameliorated cellular hallmarks of myotonic dystrophy in hybrid myotubes from patient and unaffected donor cells.

Journal: Stem cell research & therapy

Published: July 05, 2024

Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease reveal shared and tissue-specific effects.

Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease reveal shared and tissue-specific effects.

Journal: bioRxiv : the preprint server for biology

Published: July 01, 2024

Age-dependent somatic expansion of the ATXN3 CAG repeat in the blood and buccal swab DNA of individuals with spinocerebellar ataxia type 3/Machado-Joseph disease.

Age-dependent somatic expansion of the ATXN3 CAG repeat in the blood and buccal swab DNA of individuals with spinocerebellar ataxia type 3/Machado-Joseph disease.

Journal: Human genetics

Published: April 26, 2024

Showing 1-12 of 76

Last Updated: 09/26/2026