Darren N. Nesbeth

London, ENG WC1E7JE, United Kingdom

Last Updated: 09/26/2026

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Found 34 publications

Chronologically distributed transfection improves AAV2 and AAV2/8 capsid filling and reveals assembly schedule divergence.

Chronologically distributed transfection improves AAV2 and AAV2/8 capsid filling and reveals assembly schedule divergence.

Journal: Molecular therapy. Methods & clinical development

Published: July 17, 2025

Novel approaches to engineering autolysis: A scalable alternative for recovery of bioproducts.

Novel approaches to engineering autolysis: A scalable alternative for recovery of bioproducts.

Journal: Journal of biotechnology

Published: March 07, 2025

Genetically Encoded Trensor Circuits Report HeLa Cell Treatment with Polyplexed Plasmid DNA and Small-Molecule Transfection Modulators.

Genetically Encoded Trensor Circuits Report HeLa Cell Treatment with Polyplexed Plasmid DNA and Small-Molecule Transfection Modulators.

Journal: ACS synthetic biology

Published: September 06, 2024

BAKE: a novel framework for iterative security design for identifying criminally-exploitable vulnerabilities in biotechnology products.

BAKE: a novel framework for iterative security design for identifying criminally-exploitable vulnerabilities in biotechnology products.

Journal: Crime science

Published: July 04, 2024

Engineering an Autonucleolytic Mammalian Suspension Host Cell Line to Reduce DNA Impurity Levels in Serum-Free Lentiviral Process Streams.

Engineering an Autonucleolytic Mammalian Suspension Host Cell Line to Reduce DNA Impurity Levels in Serum-Free Lentiviral Process Streams.

Journal: ACS synthetic biology

Published: January 24, 2024

An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity.

An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity.

Journal: Molecular therapy. Methods & clinical development

Published: November 20, 2023

A Biological OR(XNOR) Logic Gate Couples Carbon Source and Transgene Expression Switching in a Komagataella phaffii (Pichia pastoris) Strain Co-producing Process-Enhancing Lipase and a Virus-like Particle (VLP) Vaccine.

A Biological OR(XNOR) Logic Gate Couples Carbon Source and Transgene Expression Switching in a Komagataella phaffii (Pichia pastoris) Strain Co-producing Process-Enhancing Lipase and a Virus-like Particle (VLP) Vaccine.

Journal: ACS synthetic biology

Published: February 27, 2023

Serum-free lentiviral vector production is compatible with medium-resident nuclease activity arising from adherent HEK293T host cells engineered with a nuclease-encoding transgene.

Serum-free lentiviral vector production is compatible with medium-resident nuclease activity arising from adherent HEK293T host cells engineered with a nuclease-encoding transgene.

Journal: Heliyon

Published: February 13, 2023

Tetracycline-mediated fluorescence correlates with passage number and β-galactosidase activity in HeLa and HEK293T cells.

Tetracycline-mediated fluorescence correlates with passage number and β-galactosidase activity in HeLa and HEK293T cells.

Journal: Biology open

Published: October 13, 2022

Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane.

Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane.

Journal: Journal of immunology research

Published: May 16, 2022

Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules.

Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules.

Journal: Frontiers in immunology

Published: March 22, 2022

Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei.

Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei.

Journal: Heliyon

Published: July 13, 2021

Showing 1-12 of 34

Last Updated: 09/26/2026