Darryl S. Pickering

Copenhagen, 2100, Denmark

Last Updated: 09/26/2026

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Found 62 publications

Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).

Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).

Journal: Journal of medicinal chemistry

Published: August 12, 2024

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538.

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538.

Journal: Journal of structural biology

Published: November 20, 2023

The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.

The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.

Journal: FEBS letters

Published: November 16, 2023

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.

Journal: European journal of medicinal chemistry

Published: October 24, 2023

Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand.

Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand.

Journal: Journal of labelled compounds & radiopharmaceuticals

Published: October 02, 2023

Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.

Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.

Journal: The FEBS journal

Published: July 06, 2023

Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists.

Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists.

Journal: ChemMedChem

Published: May 24, 2023

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype.

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype.

Journal: International journal of molecular sciences

Published: July 12, 2022

(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist.

(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist.

Journal: ACS chemical neuroscience

Published: April 27, 2022

Structural basis for positive allosteric modulation of AMPA and kainate receptors.

Structural basis for positive allosteric modulation of AMPA and kainate receptors.

Journal: The Journal of physiology

Published: January 26, 2021

Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.

Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.

Journal: ACS chemical neuroscience

Published: May 22, 2020

A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors.

A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors.

Journal: ACS chemical neuroscience

Published: February 19, 2020

Showing 1-12 of 62

Last Updated: 09/26/2026