David Barros - Publications

Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in Mycobacterium tuberculosis by the Novel Drug Candidate GSK2556286.

Journal: Antimicrobial agents and chemotherapy

Published: January 05, 2023

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.

Journal: Antimicrobial agents and chemotherapy

Published: May 24, 2022

UNITE4TB: a new consortium for clinical drug and regimen development for TB.

Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Published: October 23, 2021

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.

Journal: Journal of medicinal chemistry

Published: December 01, 2018

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Journal: ChemMedChem

Published: December 11, 2017

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

Journal: Journal of medicinal chemistry

Published: September 28, 2017

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.

Journal: Frontiers in pharmacology

Published: July 24, 2017

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

Journal: Scientific reports

Published: May 31, 2017

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.

Journal: ACS infectious diseases

Published: May 06, 2017

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.

Journal: Scientific reports

Published: July 06, 2016

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Journal: Antimicrobial agents and chemotherapy

Published: June 23, 2016

Repurposing clinically approved cephalosporins for tuberculosis therapy.

Journal: Scientific reports

Published: April 28, 2016