David G. Mcfadden

Endocrinology
5323 Harry Hines Blvd
Dallas, TX 75390

Last Updated: 09/26/2026

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Found 31 publications

Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens.

Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens.

Journal: bioRxiv : the preprint server for biology
Published: July 10, 2026

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

Journal: Science advances
Published: July 03, 2026

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

Loss of heterozygosity exposes germline mutations in complex I and drives Warburg metabolism in oncocytic carcinoma of the thyroid.

Journal: bioRxiv : the preprint server for biology
Published: December 22, 2025

CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma.

CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma.

Journal: Cancer discovery
Published: August 01, 2025

Endogenous EWSR1-FLI1 degron alleles enable control of fusion oncoprotein expression in tumor cell lines and xenografts.

Endogenous EWSR1-FLI1 degron alleles enable control of fusion oncoprotein expression in tumor cell lines and xenografts.

Journal: bioRxiv : the preprint server for biology
Published: November 18, 2024

Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors.

Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors.

Journal: ACS chemical biology
Published: January 25, 2024

Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors.

Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors.

Journal: bioRxiv : the preprint server for biology
Published: October 09, 2023

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Journal: bioRxiv : the preprint server for biology
Published: March 03, 2023

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.

Journal: Cell chemical biology
Published: February 16, 2023

Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid.

Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid.

Journal: Cancer discovery
Published: September 01, 2022

Differential requirements for mitochondrial electron transport chain components in the adult murine liver.

Differential requirements for mitochondrial electron transport chain components in the adult murine liver.

Journal: eLife
Published: June 09, 2022

Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.

Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.

Journal: Nature aging
Published: March 28, 2022
Showing 1-12 of 31

Last Updated: 09/26/2026