David H. Ngai

1 King's College Circle
Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 18 publications

Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis.

Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis.

Journal: Circulation

Published: September 08, 2026

Efferocytosis activates a DNMT3A-mediated oxidized DNA repair pathway to enable tissue resolution.

Efferocytosis activates a DNMT3A-mediated oxidized DNA repair pathway to enable tissue resolution.

Journal: The Journal of clinical investigation

Published: July 21, 2026

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution.

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution.

Journal: bioRxiv : the preprint server for biology

Published: May 07, 2026

Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2V617F Clonal Hematopoiesis.

Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2V617F Clonal Hematopoiesis.

Journal: JACC. Basic to translational science

Published: December 06, 2025

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2 V617F clonal hematopoiesis-driven atherosclerosis.

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2 V617F clonal hematopoiesis-driven atherosclerosis.

Journal: bioRxiv : the preprint server for biology

Published: June 12, 2025

Publisher Correction: Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution.

Publisher Correction: Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution.

Journal: Nature metabolism

Published: September 16, 2024

Crosstalk between efferocytic myeloid cells and T-cells and its relevance to atherosclerosis.

Crosstalk between efferocytic myeloid cells and T-cells and its relevance to atherosclerosis.

Journal: Frontiers in immunology

Published: March 18, 2024

Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution.

Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution.

Journal: Nature metabolism

Published: February 03, 2024

Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair.

Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair.

Journal: Nature metabolism

Published: May 15, 2023

The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation.

The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation.

Journal: Immunological reviews

Published: March 02, 2023

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages.

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages.

Journal: Nature metabolism

Published: August 16, 2022

Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis.

Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis.

Journal: Matrix biology : journal of the International Society for Matrix Biology

Published: August 16, 2021

Showing 1-12 of 18

Last Updated: 09/26/2026