David J. Vocadlo

8888 University Drive, V5S 1P6
Burnaby, BC, Canada

Last Updated: 09/26/2026

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Found 121 publications

Synthesis and Evaluation of Iminosugar-Based Analogs of UDP-GlcNAc as Putative OGT Inhibitors.

Synthesis and Evaluation of Iminosugar-Based Analogs of UDP-GlcNAc as Putative OGT Inhibitors.

Journal: ChemMedChem

Published: February 12, 2026

Pharmacological inhibition of O-GlcNAcase reduces pS129-α-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice.

Pharmacological inhibition of O-GlcNAcase reduces pS129-α-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice.

Journal: Journal of Parkinson's disease

Published: February 10, 2026

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.

Journal: bioRxiv : the preprint server for biology

Published: October 01, 2025

A proto-aldehyde fluorescence quenched substrate for quantitative imaging of both protein and enzyme activity within cells.

A proto-aldehyde fluorescence quenched substrate for quantitative imaging of both protein and enzyme activity within cells.

Journal: Chemical science

Published: June 25, 2025

A Genetically Encoded Assay System to Quantify O-GlcNAc Transferase (OGT) Activity in Live Cells.

A Genetically Encoded Assay System to Quantify O-GlcNAc Transferase (OGT) Activity in Live Cells.

Journal: Angewandte Chemie (International ed. in English)

Published: June 17, 2025

A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells.

A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells.

Journal: RSC chemical biology

Published: February 25, 2025

Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's Disease.

Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's Disease.

Journal: ACS central science

Published: February 06, 2025

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.

Journal: Molecular neurodegeneration

Published: December 09, 2024

High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.

High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 10, 2024

A gram-scale synthesis of β-L-carbafucose for engineering antibody glycans.

A gram-scale synthesis of β-L-carbafucose for engineering antibody glycans.

Journal: Communications chemistry

Published: October 06, 2024

A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases.

A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases.

Journal: Glycobiology

Published: October 02, 2024

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates.

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates.

Journal: ACS catalysis

Published: July 30, 2024

Showing 1-12 of 121

Last Updated: 09/26/2026