David J. Tweardy

Infectious Disease
210 Ashville Ave # 408
Cary, NC 27518

Last Updated: 09/26/2026

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Found 67 publications

STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer.

STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer.

Journal: International journal of molecular sciences
Published: September 12, 2025

BCM-MD Anderson onco-medicine track: a novel internal medicine residency pathway to strengthen the supportive cancer care workforce.

BCM-MD Anderson onco-medicine track: a novel internal medicine residency pathway to strengthen the supportive cancer care workforce.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Published: August 12, 2025

Update on Structure and Function of SH2 Domains: Mechanisms and Emerging Targeting Strategies.

Update on Structure and Function of SH2 Domains: Mechanisms and Emerging Targeting Strategies.

Journal: International journal of molecular sciences
Published: July 29, 2025

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer.

Journal: NPJ precision oncology
Published: February 14, 2025

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.

Journal: Frontiers in immunology
Published: February 11, 2025

Phase I Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3, in Patients with Advanced Solid Tumors.

Phase I Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3, in Patients with Advanced Solid Tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published: September 13, 2024

Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis.

Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis.

Journal: Cancers
Published: April 15, 2023

Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn's Disease.

Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn's Disease.

Journal: Journal of clinical medicine
Published: October 20, 2022

Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease.

Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease.

Journal: JHEP reports : innovation in hepatology
Published: May 09, 2022

Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers.

Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers.

Journal: Blood
Published: January 19, 2022

Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688].

Journal: Biochemical pharmacology
Published: December 05, 2021

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy.

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy.

Journal: Frontiers in cellular and infection microbiology
Published: May 11, 2021
Showing 1-12 of 67

Last Updated: 09/26/2026