David L. Jakeman

5968 College Street
Halifax, NS, Canada

Last Updated: 09/26/2026

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Found 52 publications

ortho-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase.

ortho-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase.

Journal: RSC chemical biology

Published: February 23, 2026

Development of a spectrophotometric assay for high-throughput screening and mechanistic characterization of glucose-1-phosphate thymidylyltransferase inhibitors.

Development of a spectrophotometric assay for high-throughput screening and mechanistic characterization of glucose-1-phosphate thymidylyltransferase inhibitors.

Journal: RSC chemical biology

Published: January 05, 2026

Inhibition of glycoprotein biosynthesis in the pathogenic bacterium Helicobacter pylori by masked carbohydrate phosphonates.

Inhibition of glycoprotein biosynthesis in the pathogenic bacterium Helicobacter pylori by masked carbohydrate phosphonates.

Journal: Chemical communications (Cambridge, England)

Published: December 06, 2025

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics.

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: October 17, 2025

Synthesis and physicochemical evaluation of phosphorus(III) and phosphorus(V) substituted benzoxaboroles.

Synthesis and physicochemical evaluation of phosphorus(III) and phosphorus(V) substituted benzoxaboroles.

Journal: Organic & biomolecular chemistry

Published: August 29, 2025

Amino-acid derived benzazaboroles: structure and function of a new chemotype.

Amino-acid derived benzazaboroles: structure and function of a new chemotype.

Journal: Organic & biomolecular chemistry

Published: August 15, 2025

A novel bis-phosphonyl C-glycoside: the first synthesis of C-(1,6-deoxy-β-D-glucopyranosyl)dimethylphosphonate, a stable bisphosphonate to probe the mechanism of β-phosphoglucomutase.

A novel bis-phosphonyl C-glycoside: the first synthesis of C-(1,6-deoxy-β-D-glucopyranosyl)dimethylphosphonate, a stable bisphosphonate to probe the mechanism of β-phosphoglucomutase.

Journal: Organic & biomolecular chemistry

Published: December 17, 2024

Acquired resistance to jadomycin B in human triple-negative breast cancer cells is associated with increased cyclooxygenase-2 expression.

Acquired resistance to jadomycin B in human triple-negative breast cancer cells is associated with increased cyclooxygenase-2 expression.

Journal: The Journal of pharmacology and experimental therapeutics

Published: November 15, 2024

BODIPYs α-appended with distyryl-linked aryl bisboronic acids: single-step cell staining and turn-on fluorescence binding with D-glucose.

BODIPYs α-appended with distyryl-linked aryl bisboronic acids: single-step cell staining and turn-on fluorescence binding with D-glucose.

Journal: Organic & biomolecular chemistry

Published: August 27, 2024

Synthesis of the O antigen repeating units of Escherichia coli serotypes O117 and O107.

Synthesis of the O antigen repeating units of Escherichia coli serotypes O117 and O107.

Journal: Glycobiology

Published: June 17, 2024

Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase.

Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase.

Journal: Carbohydrate research

Published: August 25, 2023

Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.

Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.

Journal: Canadian journal of physiology and pharmacology

Published: February 27, 2023

Showing 1-12 of 52

Last Updated: 09/26/2026