David L. Pearce

Nephrology

1001 Potrero Ave
San Francisco, CA 94110

Last Updated: 09/26/2026

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Found 30 publications

Roles of WNK1 and mTORC2 in aldosterone-independent regulation of potassium secretion in the distal nephron.

Roles of WNK1 and mTORC2 in aldosterone-independent regulation of potassium secretion in the distal nephron.

Journal: Kidney international

Published: November 06, 2025

Correction: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.

Correction: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.

Journal: Cell death & disease

Published: April 03, 2025

Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium.

Coordinated Regulation of Renal Glucose Reabsorption and Gluconeogenesis by mTORC2 and Potassium.

Journal: Journal of the American Society of Nephrology : JASN

Published: September 21, 2024

Aldosterone-independent regulation of K + secretion in the distal nephron.

Aldosterone-independent regulation of K + secretion in the distal nephron.

Journal: Current opinion in nephrology and hypertension

Published: June 18, 2024

Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity.

Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity.

Journal: Pflugers Archiv : European journal of physiology

Published: April 30, 2024

Evaluation of DNA yield from various tissue and sampling sources for use in single nucleotide polymorphism panels.

Evaluation of DNA yield from various tissue and sampling sources for use in single nucleotide polymorphism panels.

Journal: Scientific reports

Published: November 01, 2023

Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.

Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.

Journal: Journal of the American Society of Nephrology : JASN

Published: November 09, 2022

Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.

Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.

Journal: Pflugers Archiv : European journal of physiology

Published: July 04, 2022

WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.

WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.

Journal: Journal of cell science

Published: June 08, 2022

Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.

Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.

Journal: The Journal of biological chemistry

Published: April 25, 2022

Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.

Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.

Journal: Journal of the Endocrine Society

Published: March 02, 2022

Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.

Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.

Journal: The Journal of biological chemistry

Published: November 25, 2020

Showing 1-12 of 30

Last Updated: 09/26/2026