David L. Tyrrell

Edmonton, AB T6G2H7, Canada

Last Updated: 09/26/2026

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Found 75 publications

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor.

Identification of a Potent Pan-Coronaviral Main Protease Inhibitor.

Journal: Journal of medicinal chemistry

Published: July 16, 2026

Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle-mediated infection in humanized liver chimeric mouse models.

Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle-mediated infection in humanized liver chimeric mouse models.

Journal: Science advances

Published: May 29, 2026

Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease.

Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease.

Journal: ACS medicinal chemistry letters

Published: September 05, 2024

A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers.

A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers.

Journal: Trials

Published: August 27, 2024

Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.

Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.

Journal: Journal of thrombosis and haemostasis : JTH

Published: July 26, 2024

Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone.

Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone.

Journal: Journal of hepatology

Published: February 05, 2024

Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody-mediated tissue factor procoagulant activity in cultured endothelial cells.

Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody-mediated tissue factor procoagulant activity in cultured endothelial cells.

Journal: Journal of thrombosis and haemostasis : JTH

Published: December 02, 2023

Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles.

Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles.

Journal: Microbiology spectrum

Published: September 07, 2023

Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1.

Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Published: July 27, 2023

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

Journal: ACS bio & med chem Au

Published: June 28, 2023

Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model.

Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Published: March 23, 2023

On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads.

On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads.

Journal: ACS measurement science au

Published: February 14, 2023

Showing 1-12 of 75

Last Updated: 09/26/2026