David M. Helfman

Daejeon, Republic of Korea

Last Updated: 09/26/2026

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Found 9 publications

Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration.

Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration.

Journal: Scientific reports
Published: May 22, 2024

AKT drives sustained motility following MEK inhibition via promoting SNAIL and AXL in MDA-MB-231 LM2.

AKT drives sustained motility following MEK inhibition via promoting SNAIL and AXL in MDA-MB-231 LM2.

Journal: Biochemical and biophysical research communications
Published: April 16, 2020

Up-regulated fibronectin in 3D culture facilitates spreading of triple negative breast cancer cells on 2D through integrin β-5 and Src.

Up-regulated fibronectin in 3D culture facilitates spreading of triple negative breast cancer cells on 2D through integrin β-5 and Src.

Journal: Scientific reports
Published: January 21, 2019

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.

Journal: Oncotarget
Published: December 14, 2016

Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells.

Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells.

Journal: Oncotarget
Published: November 17, 2016

Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.

Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.

Journal: Oncotarget
Published: February 18, 2016

Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.

Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.

Journal: Oncogene
Published: July 22, 2015

Modeling of Menkes disease via human induced pluripotent stem cells.

Modeling of Menkes disease via human induced pluripotent stem cells.

Journal: Biochemical and biophysical research communications
Published: December 24, 2013

The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2.

The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2.

Journal: Oncogene
Published: March 17, 2013
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Last Updated: 09/26/2026