David M. Thal
Parkville, VIC 3052, Australia
Last Updated: 09/26/2026
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Found 48 publications
The Design, Synthesis and Pharmacological Characterization of Potent Xanomeline-Based M1 and M4 mAChR Bitopic Ligands.
Journal: Journal of medicinal chemistry
Published: July 27, 2026
Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.
Journal: ACS chemical neuroscience
Published: June 30, 2026
The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.
Journal: British journal of pharmacology
Published: December 29, 2025
Structure-guided allosteric modulation of the delta opioid receptor.
Journal: bioRxiv : the preprint server for biology
Published: November 24, 2025
Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.
Journal: Signal transduction and targeted therapy
Published: October 09, 2025
Structural basis for Porcupine inhibition.
Journal: Communications chemistry
Published: August 21, 2025
A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor.
Journal: ACS chemical neuroscience
Published: July 18, 2025
The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders.
Journal: Journal of medicinal chemistry
Published: April 16, 2025
Cryo-EM reveals a new allosteric binding site at the M5 mAChR.
Journal: bioRxiv : the preprint server for biology
Published: February 20, 2025
Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR.
Journal: Nature communications
Published: February 05, 2025
High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub-200-keV direct electron detector.
Journal: Science advances
Published: January 03, 2025
Correction: Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors.
Journal: The Journal of general physiology
Published: December 19, 2024
Last Updated: 09/26/2026