David Malinak

Hradec Kralove, KR 50003, Czech Republic

Last Updated: 09/26/2026

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Found 48 publications

Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction.

Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction.

Journal: Journal of medicinal chemistry

Published: May 06, 2026

Non-oxime reactivators of organophosphate-inhibited cholinesterases.

Non-oxime reactivators of organophosphate-inhibited cholinesterases.

Journal: Archives of toxicology

Published: April 14, 2025

N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation.

N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation.

Journal: European journal of medicinal chemistry

Published: February 16, 2025

Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases.

Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases.

Journal: ACS medicinal chemistry letters

Published: September 23, 2024

Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes.

Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes.

Journal: Bioorganic chemistry

Published: September 06, 2024

Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds.

Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds.

Journal: Bioorganic chemistry

Published: February 27, 2024

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Journal: Archives of toxicology

Published: January 17, 2024

Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition.

Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition.

Journal: European journal of medicinal chemistry

Published: November 28, 2023

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: July 25, 2023

BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS.

BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: July 01, 2023

Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells.

Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells.

Journal: Archives of toxicology

Published: May 29, 2023

Strategies for enhanced bioavailability of oxime reactivators in the central nervous system.

Strategies for enhanced bioavailability of oxime reactivators in the central nervous system.

Journal: Archives of toxicology

Published: March 10, 2023

Showing 1-12 of 48

Last Updated: 09/26/2026