David M. Sansom
University Of Birmingham Medical School Vincent Drive
Birmingham, ENG, United Kingdom
Birmingham, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 58 publications
An imbalance between CD80 and CD86 levels and CD4 regulatory T cell number and transendocytosis function exists in the liver in autoimmune hepatitis.
Journal: Clinical and experimental immunology
Published: July 24, 2025
Immune dysregulation from a novel CTLA-4 haploinsufficiency variant.
Journal: Journal of human immunity
Published: June 07, 2025
CD28 and TCR differentially impact naïve and memory T cell responses.
Journal: Discovery immunology
Published: December 16, 2024
Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction.
Journal: Cell reports
Published: May 09, 2024
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.
Journal: Frontiers in immunology
Published: January 22, 2024
An IL-2 mutein increases IL-10 and CTLA-4-dependent suppression of dendritic cells by regulatory T cells.
Journal: bioRxiv : the preprint server for biology
Published: December 18, 2023
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: July 24, 2023
Therapeutic gene editing of T cells to correct CTLA-4 insufficiency.
Journal: Science translational medicine
Published: October 26, 2022
In Vitro Analysis of CTLA-4-Mediated Transendocytosis by Regulatory T Cells.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: September 30, 2022
Impact of CTLA-4 checkpoint antibodies on ligand binding and Transendocytosis.
Journal: Frontiers in immunology
Published: February 08, 2022
Last Updated: 09/26/2026