David Pineiro

Madrid, MD 28035, Spain

Last Updated: 09/26/2026

Save publications for later
Sign Up
Not sure about your diagnosis?
Check Your Symptoms
Found 13 publications

Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers.

Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers.

Journal: Molecular therapy. Nucleic acids
Published: July 17, 2024

Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization.

Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization.

Journal: Pharmaceutics
Published: April 24, 2024

ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis.

ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis.

Journal: British journal of pharmacology
Published: July 04, 2023

Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial.

Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial.

Journal: JAMA neurology
Published: June 20, 2023

Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.

Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: October 19, 2022

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers.

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers.

Journal: Molecular therapy. Nucleic acids
Published: August 09, 2021

Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction.

Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction.

Journal: Biomolecules
Published: June 23, 2020

G3BP1 interacts directly with the FMDV IRES and negatively regulates translation.

G3BP1 interacts directly with the FMDV IRES and negatively regulates translation.

Journal: The FEBS journal
Published: January 31, 2017

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation.

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation.

Journal: Nucleic acids research
Published: March 07, 2014

Evolutionary conserved motifs constrain the RNA structure organization of picornavirus IRES.

Evolutionary conserved motifs constrain the RNA structure organization of picornavirus IRES.

Journal: FEBS letters
Published: February 08, 2013

Gemin5 promotes IRES interaction and translation control through its C-terminal region.

Gemin5 promotes IRES interaction and translation control through its C-terminal region.

Journal: Nucleic acids research
Published: December 11, 2012

Gemin5 proteolysis reveals a novel motif to identify L protease targets.

Gemin5 proteolysis reveals a novel motif to identify L protease targets.

Journal: Nucleic acids research
Published: February 25, 2012
Showing 1-12 of 13

Last Updated: 09/26/2026