David R. Edgell

London, ON N6A5C1, Canada

Last Updated: 09/26/2026

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Found 45 publications

The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and their reconstructed ancestors.

The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and their reconstructed ancestors.

Journal: bioRxiv : the preprint server for biology
Published: July 29, 2026

PHYCUT: Scalable Multiplex CRISPR/Cas9 Editing for Genome Engineering in the Diatom Phaeodactylum tricornutum.

PHYCUT: Scalable Multiplex CRISPR/Cas9 Editing for Genome Engineering in the Diatom Phaeodactylum tricornutum.

Journal: ACS synthetic biology
Published: April 14, 2026

Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut.

Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut.

Journal: ACS synthetic biology
Published: September 07, 2025

Machine learning reveals sequence and methylation determinants of SaCas9-PAM interactions in bacteria.

Machine learning reveals sequence and methylation determinants of SaCas9-PAM interactions in bacteria.

Journal: Nucleic acids research
Published: August 25, 2025

Modular determinants of cleavage preference in GIY-YIG nucleases revealed by block-based DNA shuffling and directed evolution.

Modular determinants of cleavage preference in GIY-YIG nucleases revealed by block-based DNA shuffling and directed evolution.

Journal: Nucleic acids research
Published: July 22, 2025

Better data for better predictions: data curation improves deep learning for sgRNA/Cas9 prediction.

Better data for better predictions: data curation improves deep learning for sgRNA/Cas9 prediction.

Journal: PeerJ
Published: July 21, 2025

A buffer-tuning strategy to profile domain-specific activity of chimeric I-TevI/CRISPR gene editors in vitro.

A buffer-tuning strategy to profile domain-specific activity of chimeric I-TevI/CRISPR gene editors in vitro.

Journal: Scientific reports
Published: July 09, 2025

Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion.

Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion.

Journal: bioRxiv : the preprint server for biology
Published: February 20, 2025

Ku limits RNA-induced innate immunity to allow Alu expansion in primates.

Ku limits RNA-induced innate immunity to allow Alu expansion in primates.

Journal: Nature
Published: May 11, 2024

De Novo Synthesis of a Conjugative System from Human Gut Metagenomic Data for Targeted Delivery of Cas9 Antimicrobials.

De Novo Synthesis of a Conjugative System from Human Gut Metagenomic Data for Targeted Delivery of Cas9 Antimicrobials.

Journal: ACS synthetic biology
Published: December 04, 2023

Intein-based thermoregulated meganucleases for containment of genetic material.

Intein-based thermoregulated meganucleases for containment of genetic material.

Journal: Nucleic acids research
Published: August 23, 2023

A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets.

A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets.

Journal: Nature communications
Published: March 22, 2023
Showing 1-12 of 45

Last Updated: 09/26/2026