David Rysanek
Prague, PR 14220, Czech Republic
Last Updated: 09/26/2026
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Found 15 publications
The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities.
Journal: Bioorganic chemistry
Published: January 14, 2026
In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects.
Journal: Cancer cell international
Published: September 05, 2025
Erratum to "Frentizole derivatives with mTOR inhibiting and senomorphic properties" [Biomed. Pharmacother. 167 (2023) 115600].
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: February 09, 2025
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence.
Journal: Molecular oncology
Published: December 11, 2024
Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.
Journal: ACS pharmacology & translational science
Published: April 02, 2024
Frentizole derivatives with mTOR inhibiting and senomorphic properties.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: July 04, 2023
STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells.
Journal: Molecular medicine reports
Published: October 04, 2022
Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.
Journal: Frontiers in aging neuroscience
Published: September 19, 2022
Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.
Journal: Aging
Published: April 21, 2022
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Journal: Journal of enzyme inhibition and medicinal chemistry
Published: January 14, 2021
Molecular and morphological diversity of Zygnema and Zygnemopsis (Zygnematophyceae, Streptophyta) from Svalbard (High Arctic).
Journal: European journal of phycology
Published: December 23, 2017
Terrestrial adaptation of green algae Klebsormidium and Zygnema (Charophyta) involves diversity in photosynthetic traits but not in CO2 acquisition.
Journal: Planta
Published: June 02, 2017
Last Updated: 09/26/2026