Last Updated: 09/26/2026
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Found 19 publications
Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent.
Journal: Journal of medicinal chemistry
Published: November 19, 2024
Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations.
Journal: Bioorganic & medicinal chemistry letters
Published: April 04, 2023
Pulmonary Artery Hemorrhage Post Thoracentesis.
Journal: Cardiovascular and interventional radiology
Published: August 31, 2021
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
Journal: Journal of medicinal chemistry
Published: December 28, 2020
Computational support, not primacy, distinguishes compensatory memory reorganization in epilepsy.
Journal: Brain communications
Published: August 12, 2020
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
Journal: Journal of medicinal chemistry
Published: July 19, 2019
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Journal: Journal of medicinal chemistry
Published: July 18, 2019
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
Journal: ACS medicinal chemistry letters
Published: January 28, 2019
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Journal: Science translational medicine
Published: November 25, 2018
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Journal: Bioorganic & medicinal chemistry letters
Published: October 04, 2017
Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
Journal: MedChemComm
Published: October 10, 2016
Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341).
Journal: Journal of medicinal chemistry
Published: April 24, 2015
Last Updated: 09/26/2026