David S. Block

Infectious Disease

1717 East Monument Street, Park Building, Ground Level
Park Building, Ground Level
Baltimore, MD 21287

Last Updated: 09/26/2026

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Found 10 publications

Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1.

Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1.

Journal: bioRxiv : the preprint server for biology

Published: April 16, 2025

Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia.

Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia.

Journal: Nature microbiology

Published: April 11, 2025

Fc multimers effectively treat murine models of multiple sclerosis.

Fc multimers effectively treat murine models of multiple sclerosis.

Journal: Frontiers in immunology

Published: April 03, 2023

An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza.

An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza.

Journal: Pathogens & immunity

Published: November 18, 2021

A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity.

A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity.

Journal: JCI insight

Published: May 07, 2018

Recombinant human IgG1 based Fc multimers, with limited FcR binding capacity, can effectively inhibit complement-mediated disease.

Recombinant human IgG1 based Fc multimers, with limited FcR binding capacity, can effectively inhibit complement-mediated disease.

Journal: Journal of autoimmunity

Published: May 22, 2017

A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b.

A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b.

Journal: Blood advances

Published: October 07, 2016

Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease.

Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease.

Journal: Journal of immunology (Baltimore, Md. : 1950)

Published: August 05, 2015

Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer.

Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer.

Journal: European journal of cancer (Oxford, England : 1990)

Published: January 24, 2013

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice.

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice.

Journal: Arthritis research & therapy

Published: March 30, 2012

Showing 1-10 of 10

Last Updated: 09/26/2026