David Sychantha

Waterloo, ON N2L3G1, Canada

Last Updated: 09/26/2026

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Found 31 publications

Denuded peptidoglycan oligosaccharides enable the biochemical investigation of bacterial cell wall recognition, modification, and degradation.

Denuded peptidoglycan oligosaccharides enable the biochemical investigation of bacterial cell wall recognition, modification, and degradation.

Journal: The Journal of biological chemistry

Published: July 10, 2026

Ngt-1: A glycosyltransferase that confers resistance to three distinct antibiotic classes.

Ngt-1: A glycosyltransferase that confers resistance to three distinct antibiotic classes.

Journal: The Journal of biological chemistry

Published: February 23, 2026

A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics.

A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics.

Journal: Nature

Published: October 11, 2025

The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane-Anchored N-terminal Domain.

The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane-Anchored N-terminal Domain.

Journal: Angewandte Chemie (International ed. in English)

Published: July 29, 2025

Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system.

Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system.

Journal: bioRxiv : the preprint server for biology

Published: July 14, 2025

Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor.

Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor.

Journal: mBio

Published: January 29, 2025

A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris.

A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris.

Journal: Research square

Published: January 29, 2025

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library.

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library.

Journal: Nature communications

Published: January 13, 2025

The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins.

The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins.

Journal: The Journal of biological chemistry

Published: August 01, 2024

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.

Journal: Cell chemical biology

Published: October 16, 2023

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall.

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall.

Journal: bioRxiv : the preprint server for biology

Published: August 14, 2023

Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa.

Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa.

Journal: Nature microbiology

Published: August 01, 2023

Showing 1-12 of 31

Last Updated: 09/26/2026