Dean Nizetic

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 36 publications

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models.

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models.

Journal: Cell death & disease
Published: March 20, 2026

Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society.

Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society.

Journal: Neuromolecular medicine
Published: March 13, 2026

Single-cell atlas of the developing Down syndrome brain cortex.

Single-cell atlas of the developing Down syndrome brain cortex.

Journal: Nature medicine
Published: October 08, 2025

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.

Journal: Nature communications
Published: April 01, 2025

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21.

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21.

Journal: BBA advances
Published: October 21, 2024

It's good to know what to BACE the specificity of your inhibitors on.

It's good to know what to BACE the specificity of your inhibitors on.

Journal: The Journal of clinical investigation
Published: August 15, 2024

Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant.

Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant.

Journal: Brain : a journal of neurology
Published: October 27, 2023

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.

Journal: Molecular psychiatry
Published: July 06, 2023

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

Journal: EBioMedicine
Published: February 02, 2023

BACE2: A Promising Neuroprotective Candidate for Alzheimer's Disease.

BACE2: A Promising Neuroprotective Candidate for Alzheimer's Disease.

Journal: Journal of Alzheimer's disease : JAD
Published: December 04, 2022

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Journal: Molecular psychiatry
Published: July 17, 2021

Mechanical Stress Induces a Transient Suppression of Cytokine Secretion in Astrocytes Assessed at the Single-Cell Level with a High-Throughput Microfluidic Chip.

Mechanical Stress Induces a Transient Suppression of Cytokine Secretion in Astrocytes Assessed at the Single-Cell Level with a High-Throughput Microfluidic Chip.

Journal: Advanced healthcare materials
Published: April 11, 2021
Showing 1-12 of 36

Last Updated: 09/26/2026