Deborah F. Smith

York, ENG YO105DD, United Kingdom

Last Updated: 09/26/2026

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Found 26 publications

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

Journal: Journal of medicinal chemistry
Published: June 25, 2020

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Journal: Parasites & vectors
Published: July 29, 2019

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH.

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH.

Journal: PLoS neglected tropical diseases
Published: October 25, 2016

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.

Journal: ACS infectious diseases
Published: February 28, 2016

Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World.

Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World.

Journal: PLoS pathogens
Published: September 04, 2015

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host.

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host.

Journal: PLoS pathogens
Published: August 21, 2015

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Journal: MedChemComm
Published: June 06, 2015

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.

Journal: Chemistry & biology
Published: October 16, 2014

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Journal: Journal of medicinal chemistry
Published: September 20, 2014

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

Journal: PLoS neglected tropical diseases
Published: May 31, 2014

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.

Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.

Journal: PloS one
Published: April 10, 2014

Novel tools for characterising inter and intra chromosomal rearrangements in avian microchromosomes.

Novel tools for characterising inter and intra chromosomal rearrangements in avian microchromosomes.

Journal: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Published: April 04, 2014
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Last Updated: 09/26/2026