Deheng Sun

Suite 901, Changtai Plaza, 2889 Jinke Road
Pudong, 201203, China

Last Updated: 09/26/2026

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Found 16 publications

Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Journal: Journal of medicinal chemistry

Published: December 01, 2025

Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Journal: Journal of medicinal chemistry

Published: September 08, 2025

Design and development of novel EGFR inhibitors spanning all subgroups of EGFR mutations in non-small cell lung cancer.

Design and development of novel EGFR inhibitors spanning all subgroups of EGFR mutations in non-small cell lung cancer.

Journal: Innovation (Cambridge (Mass.))

Published: May 22, 2025

A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro.

A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro.

Journal: Nature communications

Published: March 04, 2025

Design, Synthesis, and Biological Evaluation of Novel Orally Available Covalent CDK12/13 Dual Inhibitors for the Treatment of Tumors.

Design, Synthesis, and Biological Evaluation of Novel Orally Available Covalent CDK12/13 Dual Inhibitors for the Treatment of Tumors.

Journal: Journal of medicinal chemistry

Published: February 14, 2025

Synthesis and structure-activity optimization of azepane-containing derivatives as PTPN2/PTPN1 inhibitors.

Synthesis and structure-activity optimization of azepane-containing derivatives as PTPN2/PTPN1 inhibitors.

Journal: European journal of medicinal chemistry

Published: March 05, 2024

Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors.

Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: January 29, 2024

Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S.

Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S.

Journal: ACS medicinal chemistry letters

Published: November 21, 2018

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Journal: Journal of medicinal chemistry

Published: June 16, 2018

Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors.

Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors.

Journal: Scientific reports

Published: August 30, 2016

Carbazole Aminoalcohols Induce Antiproliferation and Apoptosis of Human Tumor Cells by Inhibiting Topoisomerase I.

Carbazole Aminoalcohols Induce Antiproliferation and Apoptosis of Human Tumor Cells by Inhibiting Topoisomerase I.

Journal: ChemMedChem

Published: August 03, 2016

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Journal: Journal of medicinal chemistry

Published: July 12, 2016

Showing 1-12 of 16

Last Updated: 09/26/2026