Dehua Lu

State Key Laboratory Of Natural And Biomimetic Drugs
Beijing, 100191, China

Last Updated: 09/26/2026

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Found 24 publications

Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia.

Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia.

Journal: Journal of medicinal chemistry

Published: June 30, 2026

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression.

AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression.

Journal: Journal of medicinal chemistry

Published: July 31, 2025

Structure-Based Discovery of Quinazolin-2-amine Derivatives as Potent ROR1 Pseudokinase Inhibitors with In Vitro and In Vivo Efficacy against Triple-Negative Breast Cancer.

Structure-Based Discovery of Quinazolin-2-amine Derivatives as Potent ROR1 Pseudokinase Inhibitors with In Vitro and In Vivo Efficacy against Triple-Negative Breast Cancer.

Journal: Journal of medicinal chemistry

Published: July 30, 2025

Development of Potent SHP2 Allosteric Inhibitors: Design, Synthesis, and Evaluation with Antitumor Effects.

Development of Potent SHP2 Allosteric Inhibitors: Design, Synthesis, and Evaluation with Antitumor Effects.

Journal: Journal of medicinal chemistry

Published: March 04, 2025

Synthesis and evaluation of a novel inhibitor for the α5-GABAA receptor in the treatment of peripheral neuralgia: Evidence from MD simulation and in vivo studies.

Synthesis and evaluation of a novel inhibitor for the α5-GABAA receptor in the treatment of peripheral neuralgia: Evidence from MD simulation and in vivo studies.

Journal: British journal of pharmacology

Published: January 03, 2025

Design, synthesis, and pharmacological characterization of sulfonylurea-based NLRP3 inhibitors: Towards an effective therapeutic strategy for Alzheimer's disease.

Design, synthesis, and pharmacological characterization of sulfonylurea-based NLRP3 inhibitors: Towards an effective therapeutic strategy for Alzheimer's disease.

Journal: European journal of medicinal chemistry

Published: September 06, 2024

Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.

Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.

Journal: Bioorganic & medicinal chemistry

Published: April 27, 2023

Discovery of dual PARP and CDK6 inhibitors for triple-negative breast cancer with wild-type BRCA.

Discovery of dual PARP and CDK6 inhibitors for triple-negative breast cancer with wild-type BRCA.

Journal: Bioorganic chemistry

Published: November 21, 2022

Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.

Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.

Journal: Journal of medicinal chemistry

Published: September 25, 2022

Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.

Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.

Journal: European journal of medicinal chemistry

Published: February 14, 2022

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.

Journal: Journal of medicinal chemistry

Published: December 01, 2021

Galectin expression detected by 68Ga-galectracer PET as a predictive biomarker of radiotherapy resistance.

Galectin expression detected by 68Ga-galectracer PET as a predictive biomarker of radiotherapy resistance.

Journal: European journal of nuclear medicine and molecular imaging

Published: November 06, 2021

Showing 1-12 of 24

Last Updated: 09/26/2026