Dennis A. Smith

University Road, H91 TK33
Gaillimh, C, Ireland

Last Updated: 09/26/2026

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Found 39 publications

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Journal: Journal of medicinal chemistry

Published: June 02, 2026

Total drug's last stand on phospholipidosis: Unbound drug rules!

Total drug's last stand on phospholipidosis: Unbound drug rules!

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: August 27, 2025

Insights on Volume of Distribution of Acids.

Insights on Volume of Distribution of Acids.

Journal: Journal of medicinal chemistry

Published: August 05, 2025

Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum.

Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum.

Journal: Journal of medicinal chemistry

Published: May 12, 2025

Correction to "Dose Predictions for Drug Design".

Correction to "Dose Predictions for Drug Design".

Journal: Journal of medicinal chemistry

Published: May 07, 2025

Free Drug Concepts: A Lingering Problem in Drug Discovery.

Free Drug Concepts: A Lingering Problem in Drug Discovery.

Journal: Journal of medicinal chemistry

Published: March 21, 2025

Dose-fractionation studies of a Plasmodium phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria.

Dose-fractionation studies of a Plasmodium phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria.

Journal: Antimicrobial agents and chemotherapy

Published: August 28, 2024

Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research.

Teratogenicity is more likely a function of primary and secondary pharmacology than caused by chemically reactive metabolites: a critical evaluation of 40 years of scientific research.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: June 24, 2024

Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.

Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: December 14, 2023

Anti-infectives Developed as Racemic Drugs in the 21st Century: Norm or Exception?

Anti-infectives Developed as Racemic Drugs in the 21st Century: Norm or Exception?

Journal: ACS medicinal chemistry letters

Published: May 18, 2023

The 50th anniversary of the DMDG.

The 50th anniversary of the DMDG.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: October 10, 2022

Ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ): tunable halogenation and quinone formation using NaX/Oxone.

Ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ): tunable halogenation and quinone formation using NaX/Oxone.

Journal: Organic & biomolecular chemistry

Published: March 05, 2021

Showing 1-12 of 39

Last Updated: 09/26/2026