Derek P. Nolan

Dublin, L, Ireland

Last Updated: 09/26/2026

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Found 21 publications

Metabolic tracing reveals IL-2 driven glutaminolysis and de novo pyrimidine synthesis in human natural killer cells.

Metabolic tracing reveals IL-2 driven glutaminolysis and de novo pyrimidine synthesis in human natural killer cells.

Journal: The Journal of biological chemistry

Published: November 03, 2025

Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies.

Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies.

Journal: Journal of animal science and biotechnology

Published: September 24, 2025

STAT3 suppresses palmitic acid-induced apoptosis and fatty acid oxidation dysfunction in bovine mammary epithelial cells by transcriptionally activating CPT1A.

STAT3 suppresses palmitic acid-induced apoptosis and fatty acid oxidation dysfunction in bovine mammary epithelial cells by transcriptionally activating CPT1A.

Journal: Science China. Life sciences

Published: September 21, 2025

The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells.

The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells.

Journal: Antioxidants (Basel, Switzerland)

Published: December 20, 2021

The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2.

The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2.

Journal: Journal of immunology (Baltimore, Md. : 1950)

Published: April 30, 2021

Genetic and immunological basis of human African trypanosomiasis.

Genetic and immunological basis of human African trypanosomiasis.

Journal: Current opinion in immunology

Published: January 16, 2021

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.

Journal: Nutrients

Published: February 17, 2020

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity.

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity.

Journal: iScience

Published: December 13, 2019

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages.

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages.

Journal: Frontiers in immunology

Published: May 30, 2019

Metabolic reprogramming during the Trypanosoma brucei life cycle.

Metabolic reprogramming during the Trypanosoma brucei life cycle.

Journal: F1000Research

Published: May 18, 2017

Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: November 19, 2016

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1.

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1.

Journal: Nature communications

Published: March 09, 2015

Showing 1-12 of 21

Last Updated: 09/26/2026