Deyu Wu

State Key Laboratory Of Bioactive Substance And Function Of Natural Medicines, Chinese Academy Of Medical Sciences & Peking Union Medical College
Beijing, 100050, China

Last Updated: 09/26/2026

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Found 18 publications

Discovery and Optimization of 4-Methylquinazoline Derivatives as Highly Selective PI3Kδ Inhibitors for the Treatment of Acute Lung Injury.

Discovery and Optimization of 4-Methylquinazoline Derivatives as Highly Selective PI3Kδ Inhibitors for the Treatment of Acute Lung Injury.

Journal: Journal of medicinal chemistry

Published: May 24, 2026

Catalyst-Controlled Switchable Mono-/Di-C-H Arylation of Aromatic Amides with Arylsilanes.

Catalyst-Controlled Switchable Mono-/Di-C-H Arylation of Aromatic Amides with Arylsilanes.

Journal: Organic letters

Published: September 20, 2025

Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for Cancer Immunotherapy.

Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for Cancer Immunotherapy.

Journal: Journal of medicinal chemistry

Published: July 15, 2025

Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3-Kinase with Significant in Vivo Anticancer Efficacy.

Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3-Kinase with Significant in Vivo Anticancer Efficacy.

Journal: Journal of medicinal chemistry

Published: June 16, 2025

Design, synthesis and biological evaluation of a novel PSMA-PI3K small molecule drug conjugate.

Design, synthesis and biological evaluation of a novel PSMA-PI3K small molecule drug conjugate.

Journal: RSC medicinal chemistry

Published: April 10, 2024

Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment.

Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment.

Journal: Journal of medicinal chemistry

Published: February 20, 2024

Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.

Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.

Journal: European journal of medicinal chemistry

Published: October 06, 2023

Design, synthesis, and biological evaluation of novel bivalent PI3K inhibitors for the potential treatment of cancer.

Design, synthesis, and biological evaluation of novel bivalent PI3K inhibitors for the potential treatment of cancer.

Journal: Bioorganic chemistry

Published: April 13, 2023

Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.

Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.

Journal: Journal of medicinal chemistry

Published: December 13, 2022

Cp*CoIII-catalyzed formal [4 + 2] cycloaddition of 2-phenyl-1H-imidazoles to afford imidazo[1,2-c]quinazoline derivatives.

Cp*CoIII-catalyzed formal [4 + 2] cycloaddition of 2-phenyl-1H-imidazoles to afford imidazo[1,2-c]quinazoline derivatives.

Journal: Organic & biomolecular chemistry

Published: June 13, 2022

Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.

Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.

Journal: Journal of medicinal chemistry

Published: May 24, 2022

Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma.

Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma.

Journal: Bioorganic & medicinal chemistry letters

Published: May 04, 2022

Showing 1-12 of 18

Last Updated: 09/26/2026