Dieter Dorsch
Frankfurter Str. 250
64293, Germany
64293, Germany
Last Updated: 09/26/2026
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Found 9 publications
M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer.
Journal: Molecular cancer therapeutics
Published: August 15, 2024
Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
Journal: Journal of medicinal chemistry
Published: February 02, 2023
Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.
Journal: Journal of medicinal chemistry
Published: July 13, 2021
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
Journal: Journal of chemical information and modeling
Published: August 20, 2020
Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.
Journal: Journal of medicinal chemistry
Published: August 06, 2019
Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.
Journal: The Journal of biological chemistry
Published: October 21, 2018
Discovery of novel 7-azaindoles as PDK1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters
Published: March 21, 2016
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters
Published: December 18, 2014
EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published: April 05, 2013
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Last Updated: 09/26/2026