Dieter Langosch

Freising, BY 85354, Germany

Last Updated: 09/26/2026

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Found 34 publications

Conformational Flexibility of Transmembrane Helices: How it Works and Where it Matters.

Conformational Flexibility of Transmembrane Helices: How it Works and Where it Matters.

Journal: Chemical reviews

Published: February 25, 2026

Charting γ-secretase substrates by explainable AI.

Charting γ-secretase substrates by explainable AI.

Journal: Nature communications

Published: June 25, 2024

Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices-A Methodological Approach.

Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices-A Methodological Approach.

Journal: International journal of molecular sciences

Published: July 27, 2023

Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase.

Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase.

Journal: Journal of molecular biology

Published: April 28, 2023

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.

Journal: The Journal of biological chemistry

Published: December 09, 2022

Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.

Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.

Journal: Scientific reports

Published: April 22, 2022

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity.

Journal: EMBO molecular medicine

Published: March 30, 2022

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase.

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase.

Journal: Communications biology

Published: March 18, 2022

Site-Specific Fragmentation of Green Fluorescent Protein Induced by Blue Light.

Site-Specific Fragmentation of Green Fluorescent Protein Induced by Blue Light.

Journal: Biochemistry

Published: July 27, 2021

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.

Journal: iScience

Published: August 17, 2020

Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion.

Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion.

Journal: Biochimica et biophysica acta. Biomembranes

Published: May 15, 2020

Author Correction: Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions.

Author Correction: Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions.

Journal: Scientific reports

Published: April 26, 2020

Showing 1-12 of 34

Last Updated: 09/26/2026