Dirk A. Tourwe

Brussels, BRU 1050, Belgium

Last Updated: 09/26/2026

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Found 45 publications

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

Journal: ACS pharmacology & translational science

Published: April 23, 2024

Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.

Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.

Journal: Journal of medicinal chemistry

Published: February 12, 2024

Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management.

Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management.

Journal: Journal of peptide science : an official publication of the European Peptide Society

Published: November 14, 2022

Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.

Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.

Journal: RSC medicinal chemistry

Published: February 10, 2021

Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability.

Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability.

Journal: Bioorganic & medicinal chemistry letters

Published: February 03, 2021

Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.

Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.

Journal: Journal of medicinal chemistry

Published: November 16, 2020

Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies.

Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies.

Journal: Journal of medicinal chemistry

Published: September 09, 2020

Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.

Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.

Journal: ACS chemical neuroscience

Published: October 08, 2019

Neuromedin U and Structural Analogs: An Overview of their Structure, Function and Selectivity.

Neuromedin U and Structural Analogs: An Overview of their Structure, Function and Selectivity.

Journal: Current medicinal chemistry

Published: May 13, 2019

Trifluoromethylated Proline Surrogates as Part of "Pro-Pro" Turn-Inducing Templates.

Trifluoromethylated Proline Surrogates as Part of "Pro-Pro" Turn-Inducing Templates.

Journal: Chembiochem : a European journal of chemical biology

Published: May 03, 2019

Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

Journal: ACS medicinal chemistry letters

Published: March 03, 2018

Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence.

Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence.

Journal: Organic & biomolecular chemistry

Published: January 31, 2018

Showing 1-12 of 45

Last Updated: 09/26/2026