Dirk Schepmann

Muenster, NW 48149, Germany

Last Updated: 09/26/2026

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Found 151 publications

Diastereoselective synthesis of 1,4,8-trisubstituted perhydroquinolines as novel κ receptor agonists.

Diastereoselective synthesis of 1,4,8-trisubstituted perhydroquinolines as novel κ receptor agonists.

Journal: Organic & biomolecular chemistry

Published: May 22, 2026

Negative allosteric modulation of NMDA receptors with GluN2B subunit: synthesis of γ-amino alcohols embedded in a 1-benzoxepine scaffold.

Negative allosteric modulation of NMDA receptors with GluN2B subunit: synthesis of γ-amino alcohols embedded in a 1-benzoxepine scaffold.

Journal: RSC medicinal chemistry

Published: March 30, 2026

Forcing the phenyl moiety into the axial position by embedding the 2-phenyl-1,3-dioxane system in a tricyclic benzomorphan scaffold: design, synthesis and biological evaluation.

Forcing the phenyl moiety into the axial position by embedding the 2-phenyl-1,3-dioxane system in a tricyclic benzomorphan scaffold: design, synthesis and biological evaluation.

Journal: Organic & biomolecular chemistry

Published: February 23, 2026

Antiallodynic effect of a novel sigma-1 receptor antagonist N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide (Dicloperidine): Synthesis and combined bioevaluation.

Antiallodynic effect of a novel sigma-1 receptor antagonist N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide (Dicloperidine): Synthesis and combined bioevaluation.

Journal: Neuroscience letters

Published: January 13, 2026

Stereoselective Synthesis of Conformationally Restricted γ- and β-Amino Alcohols as GluN2B Subtype-Selective NMDA Receptor Antagonists.

Stereoselective Synthesis of Conformationally Restricted γ- and β-Amino Alcohols as GluN2B Subtype-Selective NMDA Receptor Antagonists.

Journal: Journal of medicinal chemistry

Published: December 30, 2025

Development of a MS binding assay to analyze the interactions of drugs with the ifenprodil binding site of NMDA receptors with GluN2B subunit.

Development of a MS binding assay to analyze the interactions of drugs with the ifenprodil binding site of NMDA receptors with GluN2B subunit.

Journal: Journal of pharmaceutical and biomedical analysis

Published: November 03, 2025

Synthesis and Structure-Affinity Relationships of Receptor Ligands with 1,3-Dioxane Structure.

Synthesis and Structure-Affinity Relationships of Receptor Ligands with 1,3-Dioxane Structure.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 28, 2025

Chiral pool synthesis of enantiomerically pure morphan derivatives with κ receptor affinity from (S)-perillaldehyde.

Chiral pool synthesis of enantiomerically pure morphan derivatives with κ receptor affinity from (S)-perillaldehyde.

Journal: European journal of medicinal chemistry

Published: July 25, 2025

2-{N-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ1/2 Receptors.

2-{N-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ1/2 Receptors.

Journal: International journal of molecular sciences

Published: December 19, 2024

Stereoselective Synthesis and Biological Evaluation of Perhydroquinoxaline-Based κ Receptor Agonists.

Stereoselective Synthesis and Biological Evaluation of Perhydroquinoxaline-Based κ Receptor Agonists.

Journal: International journal of molecular sciences

Published: December 12, 2024

Enantiomerically Pure Indazole Bioisosteres of Ifenprodil and Ro 25-6981 as Negative Allosteric Modulators of NMDA Receptors with the GluN2B Subunit.

Enantiomerically Pure Indazole Bioisosteres of Ifenprodil and Ro 25-6981 as Negative Allosteric Modulators of NMDA Receptors with the GluN2B Subunit.

Journal: Journal of medicinal chemistry

Published: October 17, 2024

Synthesis and structure-affinity relationships of spirocyclic σ1 receptor ligands with tetrahydropyran scaffold.

Synthesis and structure-affinity relationships of spirocyclic σ1 receptor ligands with tetrahydropyran scaffold.

Journal: European journal of medicinal chemistry

Published: September 06, 2024

Showing 1-12 of 151

Last Updated: 09/26/2026