Dominic P. Williams

Biopharmaceuticals R&D
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 57 publications

Beyond NAMs versus animal models: Context of use as the governing framework for integrated nonclinical strategies in drug development.

Beyond NAMs versus animal models: Context of use as the governing framework for integrated nonclinical strategies in drug development.

Journal: Regulatory toxicology and pharmacology : RTP

Published: July 28, 2026

Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity.

Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: May 28, 2026

Contemporary perspective and practical application of glutamate dehydrogenase in nonclinical studies.

Contemporary perspective and practical application of glutamate dehydrogenase in nonclinical studies.

Journal: Biomarkers in medicine

Published: December 02, 2025

Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017.

Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017.

Journal: Chemical research in toxicology

Published: October 13, 2025

Mitotoxic effects of the melanin-concentrating hormone receptor 1 (MCHr1) antagonist AZD1979 are influenced by mitochondrial DNA variation in HepG2 cybrids.

Mitotoxic effects of the melanin-concentrating hormone receptor 1 (MCHr1) antagonist AZD1979 are influenced by mitochondrial DNA variation in HepG2 cybrids.

Journal: Toxicology

Published: September 25, 2025

Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World.

Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World.

Journal: Chemical research in toxicology

Published: May 02, 2025

Apoptotic signatures allow early and rapid screening of drug-induced liver injury to accelerate drug discovery.

Apoptotic signatures allow early and rapid screening of drug-induced liver injury to accelerate drug discovery.

Journal: Communications medicine

Published: December 10, 2024

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates.

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates.

Journal: Toxicology research

Published: August 14, 2024

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data.

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data.

Journal: Chemical research in toxicology

Published: July 09, 2024

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted in vivo and in vitro Data.

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted in vivo and in vitro Data.

Journal: bioRxiv : the preprint server for biology

Published: June 19, 2024

In silico approaches in organ toxicity hazard assessment: current status and future needs in predicting liver toxicity.

In silico approaches in organ toxicity hazard assessment: current status and future needs in predicting liver toxicity.

Journal: Computational toxicology (Amsterdam, Netherlands)

Published: March 28, 2022

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.

Journal: Chemico-biological interactions

Published: June 23, 2021

Showing 1-12 of 57

Last Updated: 09/26/2026