Dominik Heer

Basel, BS 4070, Switzerland

Last Updated: 09/26/2026

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Found 17 publications

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Journal: ACS chemical neuroscience

Published: September 18, 2025

Machine Learning-Assisted Iterative Screening for Efficient Detection of Drug Discovery Starting Points.

Machine Learning-Assisted Iterative Screening for Efficient Detection of Drug Discovery Starting Points.

Journal: Journal of medicinal chemistry

Published: July 14, 2025

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.

Journal: Nature communications

Published: January 28, 2025

Discovery of ATP competitive PDHK1/2 dual inhibitors.

Discovery of ATP competitive PDHK1/2 dual inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: January 26, 2025

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 03, 2024

Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.

Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.

Journal: European journal of nuclear medicine and molecular imaging

Published: September 09, 2024

Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells.

Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells.

Journal: Chembiochem : a European journal of chemical biology

Published: August 27, 2024

A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.

A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase.

Journal: Angewandte Chemie (International ed. in English)

Published: July 16, 2024

Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.

Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.

Journal: Journal of medicinal chemistry

Published: January 19, 2024

Discovery of Orally Available and Brain Penetrant AEP Inhibitors.

Discovery of Orally Available and Brain Penetrant AEP Inhibitors.

Journal: Journal of medicinal chemistry

Published: December 13, 2023

Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[11C]YH132: Application in Drug Development and Neurodegenerative Diseases.

Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)-[11C]YH132: Application in Drug Development and Neurodegenerative Diseases.

Journal: Chembiochem : a European journal of chemical biology

Published: December 04, 2023

Identification of (R)-[18F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development.

Identification of (R)-[18F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Published: August 03, 2023

Showing 1-12 of 17

Last Updated: 09/26/2026