Dominique Surleraux

1682 Rue De La Valsière, 34189 Montpellier Cedex 4
Montpellier, 34189, France

Last Updated: 09/26/2026

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Found 8 publications

The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.

The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: June 20, 2017

Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.

Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.

Journal: Bioorganic & medicinal chemistry letters

Published: November 07, 2016

Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.

Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.

Journal: Bioorganic & medicinal chemistry letters

Published: November 16, 2015

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.

Journal: Future medicinal chemistry

Published: October 02, 2015

Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.

Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.

Journal: Bioorganic & medicinal chemistry letters

Published: June 03, 2015

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.

Journal: Bioorganic & medicinal chemistry letters

Published: June 01, 2015

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.

Journal: Bioorganic & medicinal chemistry letters

Published: June 24, 2014

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.

Journal: Organic & biomolecular chemistry

Published: March 22, 2012

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Last Updated: 09/26/2026