Donald J. Ogilvie

Alderley Park
Macclesfield, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 35 publications

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.

Journal: Nature cancer

Published: November 18, 2021

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor.

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor.

Journal: Haematologica

Published: January 30, 2020

Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase.

Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase.

Journal: ACS medicinal chemistry letters

Published: December 17, 2019

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.

Journal: Nature structural & molecular biology

Published: August 21, 2019

Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.

Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.

Journal: Scientific reports

Published: June 13, 2019

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Journal: Cancer cell

Published: June 12, 2019

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.

Journal: Cancer research

Published: November 20, 2018

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.

Journal: Bioorganic & medicinal chemistry letters

Published: November 13, 2018

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Journal: Journal of medicinal chemistry

Published: November 08, 2018

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.

Journal: Cancer cell

Published: September 20, 2018

Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.

Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.

Journal: Journal of medicinal chemistry

Published: September 12, 2017

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.

Journal: Bioorganic & medicinal chemistry letters

Published: July 24, 2017

Showing 1-12 of 35

Last Updated: 09/26/2026