Donald M. O'rourke

Neurosurgery

801 Spruce Street
Spruce Building, 1st Floor
Philadelphia, PA 19107

Last Updated: 09/26/2026

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Found 141 publications

Clinical, molecular, and immunologic determinants of survival in WHO-defined IDH-wildtype glioblastoma treated with radiotherapy: a large real-world cohort study.

Clinical, molecular, and immunologic determinants of survival in WHO-defined IDH-wildtype glioblastoma treated with radiotherapy: a large real-world cohort study.

Journal: Journal of neuro-oncology

Published: March 11, 2026

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

Journal: International journal of radiation oncology, biology, physics

Published: January 15, 2026

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single-Institution Series.

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single-Institution Series.

Journal: International journal of radiation oncology, biology, physics

Published: January 15, 2026

A phase 2 study of niraparib concomitant with tumor treating fields in patients with recurrent grade 4 glioma.

A phase 2 study of niraparib concomitant with tumor treating fields in patients with recurrent grade 4 glioma.

Journal: Neuro-oncology advances

Published: November 23, 2025

The development of CAR T cells for patients with CNS malignancies.

The development of CAR T cells for patients with CNS malignancies.

Journal: Nature reviews. Clinical oncology

Published: October 30, 2025

Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.

Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Published: October 29, 2025

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.

Journal: Science advances

Published: October 15, 2025

Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma.

Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma.

Journal: JCO precision oncology

Published: September 04, 2025

Topical Resiquimod Elicits Systemic Protection and Improves Anti-PD-1 Therapy in Melanoma via Priming of CD8+ T Cells.

Topical Resiquimod Elicits Systemic Protection and Improves Anti-PD-1 Therapy in Melanoma via Priming of CD8+ T Cells.

Journal: Cancer immunology research

Published: August 11, 2025

Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma.

Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma.

Journal: International journal of cancer

Published: August 05, 2025

Intratumoral preservation of the stem-like malignant cell proportion in glioblastoma, prognostic impact, and its radiomethylomic signatures.

Intratumoral preservation of the stem-like malignant cell proportion in glioblastoma, prognostic impact, and its radiomethylomic signatures.

Journal: Neuro-oncology

Published: July 29, 2025

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Journal: Cell

Published: July 28, 2025

Showing 1-12 of 141

Last Updated: 09/26/2026