Donatella Boschi

Via P. Giuria 9
Turin, 10125, Italy

Last Updated: 09/26/2026

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Found 45 publications

Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.

Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.

Journal: European journal of medicinal chemistry

Published: January 27, 2026

Structure-based design of new pyrazole inhibitors targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).

Structure-based design of new pyrazole inhibitors targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).

Journal: European journal of medicinal chemistry

Published: December 22, 2025

Fluorescent Isostere (Fluostere) of the Carboxylate: Design of hDHODH Fluorescent Inhibitors as Proof of Concept.

Fluorescent Isostere (Fluostere) of the Carboxylate: Design of hDHODH Fluorescent Inhibitors as Proof of Concept.

Journal: Journal of medicinal chemistry

Published: June 18, 2025

DHODH inhibitors: What will it take to get them into the clinic as antivirals?

DHODH inhibitors: What will it take to get them into the clinic as antivirals?

Journal: Antiviral research

Published: December 03, 2024

AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications.

AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications.

Journal: ACS medicinal chemistry letters

Published: March 31, 2024

Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents.

Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents.

Journal: Mini reviews in medicinal chemistry

Published: February 22, 2024

Tandem mass spectrometry of homologous 3-hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes.

Tandem mass spectrometry of homologous 3-hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes.

Journal: Journal of mass spectrometry : JMS

Published: February 09, 2024

An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.

An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.

Journal: Acta crystallographica. Section D, Structural biology

Published: January 30, 2024

Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.

Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.

Journal: European journal of medicinal chemistry

Published: December 14, 2023

Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans.

Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans.

Journal: European journal of mass spectrometry (Chichester, England)

Published: November 17, 2023

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis.

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis.

Journal: Biomolecules

Published: July 31, 2023

Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication.

Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication.

Journal: Antiviral research

Published: July 25, 2023

Showing 1-12 of 45

Last Updated: 09/26/2026