Dorit B. Hoffmann
Kuopio, 70211, Finland
Last Updated: 09/26/2026
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Found 18 publications
Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: October 31, 2025
Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.
Journal: Alzheimer's research & therapy
Published: October 07, 2025
Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show changes in energy metabolism but no cell pathologies.
Journal: Biochimica et biophysica acta. Molecular cell research
Published: September 01, 2025
The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.
Journal: Journal of neuroinflammation
Published: November 21, 2024
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.
Journal: Molecular psychiatry
Published: April 11, 2024
Anti-GluA3 autoantibodies define a new sub-population of frontotemporal lobar degeneration patients with distinct neuropathological features.
Journal: Brain, behavior, and immunity
Published: May 24, 2023
Patient-derived skin fibroblasts as a model to study frontotemporal lobar degeneration.
Journal: Neural regeneration research
Published: June 06, 2022
C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction.
Journal: Neurobiology of disease
Published: June 03, 2021
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches.
Journal: Molecular psychiatry
Published: May 14, 2021
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62.
Journal: Molecular neurobiology
Published: February 24, 2021
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Journal: Biochimica et biophysica acta. Molecular cell research
Published: September 09, 2020
Last Updated: 09/26/2026