Dorthe Holdhof

Hamburg, HH, Germany

Last Updated: 09/26/2026

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Found 20 publications

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.

Journal: Nature communications

Published: March 08, 2024

SMARCA4 Loss and Mutated β-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum.

SMARCA4 Loss and Mutated β-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: August 24, 2023

MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice.

MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice.

Journal: Acta neuropathologica communications

Published: July 12, 2023

Molecular refinement of pilocytic astrocytoma in adult patients.

Molecular refinement of pilocytic astrocytoma in adult patients.

Journal: Neuropathology and applied neurobiology

Published: June 07, 2023

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.

Journal: Nature communications

Published: April 02, 2023

A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice.

A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice.

Journal: Cellular and molecular neurobiology

Published: January 30, 2023

The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice.

The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice.

Journal: Oncogenesis

Published: December 16, 2022

Generation of new transgenic SMARCA4-deficient mouse models results in neuromuscular weakness and paralysis of limbs.

Generation of new transgenic SMARCA4-deficient mouse models results in neuromuscular weakness and paralysis of limbs.

Journal: Brain pathology (Zurich, Switzerland)

Published: September 14, 2022

OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.

OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: March 18, 2022

SMARCA4-deficient rhabdoid tumours show intermediate molecular features between SMARCB1-deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type.

SMARCA4-deficient rhabdoid tumours show intermediate molecular features between SMARCB1-deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type.

Journal: The Journal of pathology

Published: January 06, 2021

Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration.

Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration.

Journal: Cerebellum (London, England)

Published: November 12, 2020

An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma.

An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma.

Journal: Neuro-oncology

Published: November 11, 2020

Showing 1-12 of 20

Last Updated: 09/26/2026