Edgar Specker
FMP, Robert Rössle Str. 10
Berlin, BE 13125, Germany
Berlin, BE 13125, Germany
Last Updated: 09/26/2026
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Found 34 publications
Cell Painting Protocol to Characterize Morphological Profiles of Large Compound Collections Using the EU-OPENSCREEN Library.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: January 01, 2026
Targeting the Membrane-Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight.
Journal: Angewandte Chemie (International ed. in English)
Published: June 27, 2025
Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension.
Journal: American journal of respiratory cell and molecular biology
Published: February 03, 2025
Selectivity and Safety Characterization of a Xanthine-Imidazothiazole Lead Structure: a Novel Tryptophan Hydroxylase Inhibitor of Peripheral Serotonin Synthesis.
Journal: ACS pharmacology & translational science
Published: January 15, 2025
Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2.
Journal: European journal of immunology
Published: November 04, 2024
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats.
Journal: Journal of the American Heart Association
Published: May 10, 2024
Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4.
Journal: PloS one
Published: April 09, 2024
Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression.
Journal: JACC. Basic to translational science
Published: February 09, 2024
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Journal: RSC medicinal chemistry
Published: December 18, 2023
Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Journal: Journal of medicinal chemistry
Published: October 31, 2023
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
Journal: Journal of medicinal chemistry
Published: October 11, 2023
Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase.
Journal: Chembiochem : a European journal of chemical biology
Published: August 08, 2023
Last Updated: 09/26/2026